DuP-654
2-(苯基甲基)萘-1-醇Chemical Name: 2-Benzyl-1-naphthol; 2-(Phenylmethyl)-1-naphthalenol; 2-Benzyl-1-hydroxynaphthalene
CAS No. 36441-32-4
项目整合开发状态: Phase II
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Alkylation of the sodium salt of 1-naphthol with benzyl bromide provides DuP-654.Alternatively,condensation of 1-tetralone (I) with benzaldehyde (II) in the presence of potassium hydroxide yields 2-benzylidene-1-tetralone (III),which may be isomerized to DuP-654 using rhodium chloride or a soluble iridium complex.A mixture of (I) and (II) may also be directly converted to DuP-654 by treating with potassium tert-butoxide in refluxing tert-butanol.
📌 参考资料/链接：
参考文献标题:2-Substituted-1-naphthols as 5-lipoxygenase inhibitors
文献作者:Batt,D.G.(E.I.Du Pont de Nemours & Co.)
参考来源:AU 8657186; EP 0201071; ES 8801780; US 4833164
📄 详细内容
合成路线:Alkylation of the sodium salt of 1-naphthol with benzyl bromide provides DuP-654.Alternatively,condensation of 1-tetralone (I) with benzaldehyde (II) in the presence of potassium hydroxide yields 2-benzylidene-1-tetralone (III),which may be isomerized to DuP-654 using rhodium chloride or a soluble iridium complex.A mixture of (I) and (II) may also be directly converted to DuP-654 by treating with potassium tert-butoxide in refluxing tert-butanol.
参考文献标题:DuP-654
文献作者:Harris,R.R.; Batt,D.G.; Galbraith,W.; Gans,K.R.; Jaffee,B.D.; Kerr,J.S.; Ackerman,N.R.; Mackin,W.M.
参考来源:Drugs Fut 1989,14(11),1040
产品链接: CAS No. 36441-32-4››