Fosfosal, UR-1521, Aydolid, Disdolen
2-(膦酸氧基)苯甲酸Chemical Name: Salicylic acid dihydrogen phosphate
CAS No. 6064-83-1
项目整合开发状态: Launched-1984
项目研究机构: Uriach (Originator)
合成路线:It is prepared by treatment of 2-hydroxybenzoic acid (I) with phosphorous pentachloride.The reaction involves a first stage in which (I) is converted by PCl5 to the corresponding acyl chloride (II) upon release of phosphorous oxychloride,which reacts immediately with the free phenolic group of (II),giving rise to the acid trichloride (III).In a second stage,(III) is hydrolyzed with enough water to give the 2-phosphonoxybenzoic acid (IV).The reaction is carried out in a one-step process,which involves chlorination,phosphonation and hydrolysis,the isolation of the intermediate (III) being unnecessary.The final product is recovered from the reaction mixture by precipitation with a suitable inert organic solvent and is submitted to further purification.
📌 参考资料/链接：
参考文献标题:Fosfosal
文献作者:Francia,E.; Garc韆-Rafanell,J.; Mar韓,A.
参考来源:Drugs Fut 1980,5(6),290
📄 详细内容
合成路线:It is prepared by treatment of 2-hydroxybenzoic acid (I) with phosphorous pentachloride.The reaction involves a first stage in which (I) is converted by PCl5 to the corresponding acyl chloride (II) upon release of phosphorous oxychloride,which reacts immediately with the free phenolic group of (II),giving rise to the acid trichloride (III).In a second stage,(III) is hydrolyzed with enough water to give the 2-phosphonoxybenzoic acid (IV).The reaction is carried out in a one-step process,which involves chlorination,phosphonation and hydrolysis,the isolation of the intermediate (III) being unnecessary.The final product is recovered from the reaction mixture by precipitation with a suitable inert organic solvent and is submitted to further purification.
参考文献标题:Procedimiento de obtenci髇 del 醕ido 2-fosfonoxibenzoico y sales del mismo
文献作者:Mar韓,A.; Francia,E.
参考来源:DE 2641526; ES 460645
产品链接: CAS No. 6064-83-1››