BR-227
2-(甲基氨基)丙-2-烯酸Chemical Name: N-[2,4-Dibromo-6-(N-cyclohexyl-N-methylaminomethyl)phenyl]-4-hydroxy-3-methoxybenzamide; 2',4'-Dibromo-alpha-(cyclohexylmethylamino)-o-vanillotoluidide
CAS No. 84461-99-4
项目整合开发状态: Preclinical
项目研究机构: Abbott (Originator)
合成路线:The acylation of 2,4-dibromo-6-(N-cyclohexyl-N-methylaminomethyl)aniline (I) with 4-(ethoxycarbonyloxy)-3-methoxybenzoyl chloride (II) in CHCl3 gives the corresponding amide (III),which is deprotected by a treatment with aqueous 20% NaOH.
📌 参考资料/链接：
参考文献标题:2-Benzoylamino substituted benzylamine derivative and a process for preparation thereof
文献作者:Koshinaka,E.; Ogawa,N.; Kurata,S.; Yamagashi,K.; Kato,I.(Hokuriku Seiyaku Co.,Ltd.)
参考来源:DE 3209970; EP 0061157; ES 510608
📄 详细内容
合成路线:The acylation of 2,4-dibromo-6-(N-cyclohexyl-N-methylaminomethyl)aniline (I) with 4-(ethoxycarbonyloxy)-3-methoxybenzoyl chloride (II) in CHCl3 gives the corresponding amide (III),which is deprotected by a treatment with aqueous 20% NaOH.
参考文献标题:BR-227
文献作者:Chu,S.S.
参考来源:Drugs Fut 1985,10(3),186
产品链接: CAS No. 84461-99-4››