Carbisocaine hydrochloride, Carbizocaine hydrochloride, BK 95
2-(庚氧基)苯胺基甲酸 2-(二乙基氨基)-1-甲基乙基酯盐酸盐 1-二乙基氨基丙-2-基N-(2-庚氧基苯基)氨基甲酸酯 Chemical Name: N-(2-Heptyloxyphenyl)carbamic acid 2-(diethylamino)-1-methylethyl ester hydrochloride
CAS No. 68931-03-3, 76629-87-3 (free base)
项目整合开发状态: Clinical
项目研究机构: Res. Inst. Pharmacy Biochemistry (VUFB) (Originator), Slovak Academy of Sciences (Originator), Univ. Komenskeho, Bratislava (Originator)
合成路线:Reaction of 1,2-epoxypropane (I) and diethyl amine (II) yields 1-diethylamino-2-propanol (III).2-Heptyloxyaniline (IV) is reacted with a solution of phosgene in toluene to give 2-heptyloxyphenyliso cyanate (V),which is treated with the aminoalcohol (III) to give title compound.
📌 参考资料/链接：
参考文献标题:Carbizocaine hydrochloride
文献作者:R醖i,S.
参考来源:Drugs Fut 1986,11(7),555
📄 详细内容
合成路线:Reaction of 1,2-epoxypropane (I) and diethyl amine (II) yields 1-diethylamino-2-propanol (III).2-Heptyloxyaniline (IV) is reacted with a solution of phosgene in toluene to give 2-heptyloxyphenyliso cyanate (V),which is treated with the aminoalcohol (III) to give title compound.
参考文献标题:Studies on local anesthetics.LXV.Basic esters of o-alkoxycarbanilic acids with local-anesthetic and anti-arrhythmic effects
文献作者:Benes,L.; Svec,P.; Kozlovsky,J.; Borovansky,A.
参考来源:Cesk Farm 1978,27(4),167
合成路线:Reaction of 1,2-epoxypropane (I) and diethyl amine (II) yields 1-diethylamino-2-propanol (III).2-Heptyloxyaniline (IV) is reacted with a solution of phosgene in toluene to give 2-heptyloxyphenyliso cyanate (V),which is treated with the aminoalcohol (III) to give title compound.
参考文献标题:Basic isopropyl esters of alkoxy-subsituted carbanilics acids.Local anesthetics.XLIII
文献作者:Hartl,J.; Benes,L.; Kopacova,L.; Borovansky,A.
参考来源:Acta Fac Pharm Univ Comeniana 1973,23(2),81
产品链接: CAS No. 68931-03-3›› 产品链接: CAS No.76629-87-3››