L-Dopa ethyl ester, Etilevodopa, Levodopa ethyl ester, TV-1203
2(S)-氨基-3-(3,4-二羟基苯基)丙酸乙酯Chemical Name: 2(S)-Amino-3-(3,4-dihydroxyphenyl)propionic acid ethyl ester; 3-Hydroxy-L-tyrosine ethyl ester
CAS No. 37178-37-3
项目整合开发状态: Phase III
项目研究机构: Teva (Proprietary), Hebrew University (Originator), Lundbeck (Licensee)
合成路线:Etilevodopa has been obtained by several different methods: (i) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) with ethanol catalyzed by dry HCl gas; (ii) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) by means of SOCl2 in hot ethanol; (iii) enzymatic hydroxylation of L-tyrosine ethyl ester (II) by means of mushroom tyrosinase in a phosphate buffer.
📌 参考资料/链接：
参考文献标题:Process for preparing ethyl ester of L-DOPA
文献作者:Atlas,D.; Veinberg,A.; Melamed,E.; Milman,I.(Teva Pharmaceutical Industries Ltd.; Yissum Research Development Co.)
参考来源:EP 0610595; US 5354885
📄 详细内容
合成路线:Etilevodopa has been obtained by several different methods: (i) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) with ethanol catalyzed by dry HCl gas; (ii) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) by means of SOCl2 in hot ethanol; (iii) enzymatic hydroxylation of L-tyrosine ethyl ester (II) by means of mushroom tyrosinase in a phosphate buffer.
参考文献标题:Process for manufacture of L-DOPA ethyl ester
文献作者:Bahar,E.; Lidor,R.; Frenkel,A.(Teva Pharmaceutical Industries Ltd.; Teva Pharmaceuticals USA,Inc.)
参考来源:US 6218566; WO 0027801
合成路线:Etilevodopa has been obtained by several different methods: (i) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) with ethanol catalyzed by dry HCl gas; (ii) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) by means of SOCl2 in hot ethanol; (iii) enzymatic hydroxylation of L-tyrosine ethyl ester (II) by means of mushroom tyrosinase in a phosphate buffer.
参考文献标题:Facile synthesis of L-Dopa esters by the combined use of tyrosinase and alpha-chymotrypsin
文献作者:Ahmed,G.; Vulfson,E.N.
参考来源:Biotechnol Lett 1994,16(4),367
合成路线:Etilevodopa has been obtained by several different methods: (i) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) with ethanol catalyzed by dry HCl gas; (ii) esterification of 3-hydroxy-L-tyrosine (I) (L-DOPA) by means of SOCl2 in hot ethanol; (iii) enzymatic hydroxylation of L-tyrosine ethyl ester (II) by means of mushroom tyrosinase in a phosphate buffer.
参考文献标题:Etilevodopa
文献作者:Sorbera,L.A.; Leeson,P.; Castar,J.; Mart韓,L.
参考来源:Drugs Fut 2001,26(3),219
产品链接: CAS No. 37178-37-3››