Ameltolide, ADD-75073, LY-201116
4-氨基-N-(2,6-二甲基苯基)苯甲酰胺Chemical Name: 4-Amino-N-(2,6-dimethylphenyl)benzamide
CAS No. 787-93-9, 107293-98-1 (monoHCl)
项目整合开发状态: Phase I
项目研究机构: Lilly (Originator)
合成路线:4-Nitrobenzoylchloride (I) is condensed with 2,6-dimethylaniline (II) in the presence of base (potassium carbonate or triethylamine) to provide the 4-nitrobenzamide (III).Reduction of the aromatic nitro group in (III) using catalytic hydrogenation produces the corresponding 4-aminobenzamide,ameltolide.
📌 参考资料/链接：
参考文献标题:Anticonvulsant activity of some 4-aminobenzanilides
文献作者:Clark,C.R.; Sansom,R.T.; Lin,C.-M.; Norris,G.N.
参考来源:J Med Chem 1985,28(9),1259
📄 详细内容
合成路线:4-Nitrobenzoylchloride (I) is condensed with 2,6-dimethylaniline (II) in the presence of base (potassium carbonate or triethylamine) to provide the 4-nitrobenzamide (III).Reduction of the aromatic nitro group in (III) using catalytic hydrogenation produces the corresponding 4-aminobenzamide,ameltolide.
参考文献标题:AMELTOLIDE
文献作者:Clark,C.R.; Robertson,D.W.; Leander,J.D.
参考来源:Drugs Fut 1990,15(10),983
产品链接: CAS No. 787-93-9››