NS-1652
2-(3-(3-(三氟甲基)苯基)脲基)苯甲酸Chemical Name: 2-[3-[3-(Trifluoromethyl)phenyl]ureido]benzoic acid
CAS No. 1566-81-0
项目整合开发状态: Preclinical
项目研究机构: NeuroSearch (Originator)
合成路线:The title urea derivative was obtained by condensation of 3-(trifluoromethyl)phenyl isocyanate (I) with anthranilic acid (II).
合成路线:The target compound can be obtained by condensation of 3-trifluoromethylphenyl isocyanate (I) with 5-(2-amino-5-bromophenyl)tetrazole in toluene.
📌 参考资料/链接：
参考文献标题:Phenyl derivs.containing an acidic group,their preparation and their use as chloridic channel blockers
文献作者:Christophersen,P.; Pedersen,O.(NeuroSearch A/S)
参考来源:EP 0906273; EP 0977741; JP 2000511167; WO 9745400; WO 9847879
📄 详细内容
合成路线:The title urea derivative was obtained by condensation of 3-(trifluoromethyl)phenyl isocyanate (I) with anthranilic acid (II).
参考文献标题:Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug,flufenamic acid
文献作者:Baures,P.W.; Oza,V.B.; Peterson,S.A.; Kelly,J.W.
参考来源:Bioorg Med Chem 2000,7(7),1339
产品链接: CAS No. 1566-81-0››