APHS
2-(2-庚炔-1-基硫代)-苯酚 1-乙酸酯Chemical Name: Acetic acid 2-(2-heptynylsulfanyl)phenyl ester
CAS No. 209125-28-0
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator), Vanderbilt University (Originator)
合成路线:2-Hydroxythiophenol (I) was alkylated at the S atom with 1-bromo-2-heptyne (II) (obtained by reaction of 2-heptyn-1-ol (IV) with Ph3P and CBr4 in pyridine) in the presence of KHCO3 in DMF at r.t.to afford sulfide (III).Subsequent acetylation with Ac2O and pyridine gave the desired acetate.
📌 参考资料/链接：
参考文献标题:Selective inhibitors of prostaglandin endoperoxide synthase-2
文献作者:Marnett,L.J.; Kalgutkar,A.S.(Vanderbilt University)
参考来源:US 5973191
📄 详细内容
合成路线:2-Hydroxythiophenol (I) was alkylated at the S atom with 1-bromo-2-heptyne (II) (obtained by reaction of 2-heptyn-1-ol (IV) with Ph3P and CBr4 in pyridine) in the presence of KHCO3 in DMF at r.t.to afford sulfide (III).Subsequent acetylation with Ac2O and pyridine gave the desired acetate.
参考文献标题:Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides,a new class of selective COX-2 inactivators
文献作者:Kalgutkar,A.S.; Kozak,K.R.; Crews,B.C.; Hochgesang,G.P.Jr.; Marnett,L.J.
参考来源:J Med Chem 1998,41(24),4800
产品链接: CAS No. 209125-28-0››