FR-194921
2-(1-甲基哌啶-4-基)-6-(2-苯基吡喃[1,5-a]吡啶-3-酰)吡啶嗪-3(2H)-1Chemical Name: 2-(1-Methylpiperidin-4-yl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)pyridazin-3(2H)-one
CAS No. 202646-80-8, 202646-82-0 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Fujisawa (Originator)
合成路线:The title compound was synthesized by alkylation of the previously described 6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone (I) with 4-chloro-1-methylpiperidine (II) in the presence of NaH in hot DMF.
合成路线:An alternative procedure consisted in the Mitsunobu coupling of pyridazinone (I) with 4-hydroxy-1-methylpiperidine (III) in the presence of either diisopropyl- or diethyl azodicarboxylate and triphenylphosphine
📌 参考资料/链接：
参考文献标题:Pyrazolopyridine cpd.and pharmaceutical use thereof
文献作者:Akahane,A.; Kuroda,S.; Itani,H.; Shimizu,Y.(Fujisawa Pharmaceutical Co.,Ltd.)
参考来源:EP 0925299; JP 2000514821; US 6124456; WO 9803507
📄 详细内容
合成路线:An alternative procedure consisted in the Mitsunobu coupling of pyridazinone (I) with 4-hydroxy-1-methylpiperidine (III) in the presence of either diisopropyl- or diethyl azodicarboxylate and triphenylphosphine
参考文献标题:Design,synthesis and biological evaluation of a novel series of potent,orally active adenosine A1 receptor antagonists with high blood-brain barrier permeability
文献作者:Kuroda,S.; Takamura,F.; Tenda,Y.; Itani,H.; Tomishima,Y.; Akahane,A.; Sakane,K.
参考来源:Chem Pharm Bull 2001,49(8),988
产品链接: CAS No. 202646-80-8››