ONO-AP-324

2-((5-(3-(苄基氨基)-3-氧代丙基)萘-1-基)氧基)乙酸Chemical Name: 2-[5-[2-[N-(Diphenylmethyl)carbamoyl]ethyl]naphthalen-1-yloxy]acetic acid
CAS No. 180197-87-9
项目整合开发状态: Preclinical
项目研究机构: Ono (Originator)
合成路线:Alkylation of tert-butyl (5-hydroxy-2-naphthyl)propionate (I) with methyl bromoacetate (II) in the presence of K2CO3 provided ether (III).Subsequent deprotection of the tert-butyl ester of (III) using trifluoroacetic acid in CH2Cl2 gave carboxylic acid (IV).This was coupled to benzhydrylamine in the presence of EDC and DMAP to afford amide (VI).Finally,ester hydrolysis of (IV) with NaOH yielded the target compound.