FK-448
1-萘羧酸,1,2,3,4-四氢,4-(4-(1-甲基乙基)-1-吡嗪基)羰基)苯酯,单甲烷磺酸盐Chemical Name: 1,2,3,4-Tetrahydro-1-naphthalenecarboxylic acid 4-[[4-(1-methylethyl)-1-piperazinyl]carbonyl]phenyl ester monomethanesulfonate
CAS No. 89703-10-6
项目整合开发状态: Biological Testing
项目研究机构: Kowa (Originator)
合成路线:4-(4-isopropylpiperazinocarbonyl)phenol (IV) is obtained by reaction of 1-isopropylpiperazine (I) and 4-ethoxycarbonyloxybenzoylchloride (II) in CHCl3 using triethylamine (Et3N) as a proton scavenger,followed by removing its ethoxycarbonyl group using pyrrolidine in ethylacetate.Also,the reaction in CHCl3 of 1,2,3,4-tetrahydro-1-naphtoyl chloride (III) and (IV) using Et3N,followed by neutralization of the medium using NaOH and by salt formation using CH3SO3H in ethanol,yields FK-448.
📌 参考资料/链接：
参考文献标题:Benzoylpiperazine esters and a process for their production
文献作者:Fujii,S.; Hattori,E.; Hirata,M.; Watanabe,K.; Onogi,K.; Nagakura,M.(Kowa Co.,Ltd.)
参考来源:EP 0098713; JP 83225080; US 4898876
📄 详细内容
合成路线:4-(4-isopropylpiperazinocarbonyl)phenol (IV) is obtained by reaction of 1-isopropylpiperazine (I) and 4-ethoxycarbonyloxybenzoylchloride (II) in CHCl3 using triethylamine (Et3N) as a proton scavenger,followed by removing its ethoxycarbonyl group using pyrrolidine in ethylacetate.Also,the reaction in CHCl3 of 1,2,3,4-tetrahydro-1-naphtoyl chloride (III) and (IV) using Et3N,followed by neutralization of the medium using NaOH and by salt formation using CH3SO3H in ethanol,yields FK-448.
参考文献标题:FK-448
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(3),185
产品链接: CAS No. 89703-10-6››