D-21151
1-苯氧基二氮杂萘Chemical Name: 1-Phenoxyphthalazine
CAS No. 100537-30-2
项目整合开发状态: Preclinical
项目研究机构: Asta Medica (Originator)
合成路线:D-21151 is easily obtained by a two-step sequence starting from phthalazin-1-one (I).The treatment of (I) with phosphorus oxychloride furnishes 1-chlorophthalazine (II),which is reacted with phenol in the presence of sodium hydride to give D-21151.
📌 参考资料/链接：
参考文献标题:Phthalazines substd.on position 1 by an ether or a thioether group and process for their preparation
文献作者:Scheffler,G.; Fleischhauser,I.; Kutscher,B.; Engel,J.; Szelenyi,S.; Werner,U.(Asta Medica AG)
参考来源:DE 4234933; EP 0539805; JP 1993222002
📄 详细内容
合成路线:D-21151 is easily obtained by a two-step sequence starting from phthalazin-1-one (I).The treatment of (I) with phosphorus oxychloride furnishes 1-chlorophthalazine (II),which is reacted with phenol in the presence of sodium hydride to give D-21151.
参考文献标题:D-21151
文献作者:Engel,J.; Fleischhauer,I.; Scheffler,G.; Werner,U.; Kutscher,B.; Szelenyi,I.
参考来源:Drugs Fut 1993,18(12),1107
产品链接: CAS No. 100537-30-2››