合成路线:For [14C]-labelling of alifedrine,the following reaction sequence has been used: In the first step Friedel-Crafts'-like acylation of ethylene (A) with cyclohexanoyl chloride (VII) in the presence of aluminum chloride yields beta-chloroethylcyclohexyl ketone (VIII),which reacts with (I) to give alifedrine hydrochloride.Alifedrine has also been synthesized by catalytic hydrogenation of (V) with 1-norephedrine (I) in the presence of hydrochloric acid and paraformaldehyde.
参考文献标题:Syntheses of 14C-1-erythro-norephedrine and its N-substitution products 14C-oxyfedrine and 14C-D 13,625
文献作者:Klingler,K.G.; Engel,J.; Bickel,E.
参考来源:Arzneim-Forsch Drug Res 1983,33(9),1213
合成路线:For [14C]-labelling of alifedrine,the following reaction sequence has been used: In the first step Friedel-Crafts'-like acylation of ethylene (A) with cyclohexanoyl chloride (VII) in the presence of aluminum chloride yields beta-chloroethylcyclohexyl ketone (VIII),which reacts with (I) to give alifedrine hydrochloride.Alifedrine has also been synthesized by catalytic hydrogenation of (V) with 1-norephedrine (I) in the presence of hydrochloric acid and paraformaldehyde.
参考文献标题:Novel cycloaliphatic enamines
文献作者:Engel,J.; et al.
参考来源:DE 3213371
合成路线:Mannich reaction of acetylcyclohexane (V),paraformaldehyde and 1-norephedrine (I) in the presence of hydrochloric acid yields alifedrine hydrochloride.Mannich reaction of 1-acetylcyclohexene (VI) with paraformaldehyde and (I) followed by catalytic hydrogenation of the resulting beta-aminoketone (III) also gives alifedrine hydrochloride.
合成路线:For [14C]-labelling of alifedrine,the following reaction sequence has been used: In the first step Friedel-Crafts'-like acylation of ethylene (A) with cyclohexanoyl chloride (VII) in the presence of aluminum chloride yields beta-chloroethylcyclohexyl ketone (VIII),which reacts with (I) to give alifedrine hydrochloride.Alifedrine has also been synthesized by catalytic hydrogenation of (V) with 1-norephedrine (I) in the presence of hydrochloric acid and paraformaldehyde.
参考文献标题:Cycloaliphatic ketoamines
文献作者:Engel,J.; et al.
参考来源:DE 2919495; FR 2426040; GB 2023575; JP 54151950; US 4542159
合成路线:Alifedrine hydrochloride can be synthesized by condensation of acetylcyclohexane with the bisoxazolidine (IV),which is obtained by reaction of (I) with paraformaldehyde in aqueous solution.Finally,alifedrine can be obtained by condensation of 3-oxo-3-cyclohexylpropanal (X) and norephedrine (I) under reducing conditions (VI).
参考文献标题:
文献作者:Tr鰉er,H.G.; Sheldrick,W.S.; Engel,J.
参考来源:Chem Ztg 1982,106(Suppl.1),427
合成路线:Alifedrine hydrochloride can be synthesized by condensation of acetylcyclohexane with the bisoxazolidine (IV),which is obtained by reaction of (I) with paraformaldehyde in aqueous solution.Finally,alifedrine can be obtained by condensation of 3-oxo-3-cyclohexylpropanal (X) and norephedrine (I) under reducing conditions (VI).
参考文献标题:Cycloaliphatic ketoamines
文献作者:Engel,J.; et al.
参考来源:DE 3043350
产品链接: CAS No. 72913-80-5›› 产品链接: CAS No.78756-61-3››