D-16120
1-丙酮,3-环己基-1-[4-(2-乙氧基苯基)-1-哌拉嗪]-,盐酸盐(1:1)Chemical Name: 1-(2-Ethoxyphenyl)-4-(3-cyclohexylpropionyl)piperazine hydrochloride
CAS No. 96222-01-4
项目整合开发状态: Preclinical
项目研究机构: Degussa (Originator)
合成路线:The synthesis of D-16120 can be achieved by several methods:1) Aminolysis of 3-cyclohexylpropionyl chloride (I) with 2-ethoxyphenylpiperazine (II) in the presence of triethylamine yields D-16120.2) Reaction of ethyl 3-cyclohexylpropionate (III) with 2-ethoxyphenylpiperazine (IV) also gives D-16120.
📌 参考资料/链接：
参考文献标题:1-Cycloalkyl-3-acylpiperazine derivs.
文献作者:Engel,J.; Jakovlev,V.; Oepen,G.; Thiemer,K.(Degussa-H黮s AG)
参考来源:EP 0120465; US 4547505
📄 详细内容
合成路线:The synthesis of D-16120 can be achieved by several methods:1) Aminolysis of 3-cyclohexylpropionyl chloride (I) with 2-ethoxyphenylpiperazine (II) in the presence of triethylamine yields D-16120.2) Reaction of ethyl 3-cyclohexylpropionate (III) with 2-ethoxyphenylpiperazine (IV) also gives D-16120.
参考文献标题:D-16120
文献作者:Oepen,G.; Nickel,B.; Molliere,M.; Engel,J.
参考来源:Drugs Fut 1987,12(3),209
合成路线:The synthesis of D-16120 can be achieved by several methods:1) Aminolysis of 3-cyclohexylpropionyl chloride (I) with 2-ethoxyphenylpiperazine (II) in the presence of triethylamine yields D-16120.2) Reaction of ethyl 3-cyclohexylpropionate (III) with 2-ethoxyphenylpiperazine (IV) also gives D-16120.
参考文献标题:Metabolism of 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl)piperazine (D-16120) by rat liver microsomes
文献作者:Caputo,O.; Rocco,F.; Grosa,G.
参考来源:Eur J Drug Metab Pharmacokinet 1994,19(4),303
产品链接: CAS No. 96222-01-4››