XT-044, XT-44

1-丁基-3-丙基-3,9-二氢-1H-嘌呤-2,6-二酮Chemical Name: 1-Butyl-3-propyl-3,9-dihydro-1H-purine-2,6-dione
CAS No. 135462-05-4
项目整合开发状态: Preclinical
项目研究机构: Abbott (Originator)
合成路线:Protection of 3-propylxanthine (I) using p-methoxybenzyl chloride (II) afforded the 7-(p-methoxybenzyl) derivative (III),which was further alkylated at position 1 with butyl iodide and K2CO3 to give (IV).Finally,removal of the p-methoxybenzyl group of (IV) by means of H2SO4 in the presence of anisole in refluxing trifluoroacetic acid yielded the title xanthine.