新产品编号:299507

1H-苯并咪唑,2-(2,6-二氟苯基)-1-[(2,6-二氟苯基)甲基]-4-甲基-Chemical Name: 1-(2,6-Difluorobenzyl)-2-(2,6-difluorophenyl)-4-methyl-1H-benzimidazole
CAS No. 199594-65-5
项目整合开发状态: Biological Testing
项目研究机构: National Cancer Institute (Originator), Southern Research Institute (Originator)
合成路线:2-Methyl-6-nitroaniline (I) was acylated with 2,6-difluorobenzoyl chloride (II) to afford the nitroanilide (III).Reduction of the nitro group of (III) with concomitant cyclization using iron powder in refluxing HOAc furnished the benzimidazole (IV).Finally,N-alkylation of (IV) with 2,6-difluoro-alpha-bromotoluene (V) in the presence of NaH provided the title compound.