WAY-141839, GMA-839, Co-2-6749

19-去甲堙嘀-20-1,3,21-二羟基-3-(三氟甲基)-,(3α,5β)-Chemical Name: 3alpha,21-Dihydroxy-3beta-(trifluoromethyl)-19-nor-5beta-pregnan-20-one
CAS No. 162882-76-0
项目整合开发状态: Preclinical
项目研究机构: CoCensys (Originator), Wyeth Pharmaceuticals (Licensee)
合成路线:Oxidation of the known 3-alpha-hydroxy-3-beta-trifluoromethyl-5-beta-19-norpregnan-20-one (I) with lead tetraacetate gave the 21-acetoxy derivative (II).Subsequent hydrolysis of the acetate ester group of (II) using K2CO3 in MeOH furnished the desired alcohol along with some 21-methoxy byproduct,which were chromatographically separated.