NSC-262244, TPA

12-O-十四烷酰佛波醋酸酯-13 4α-佛波醇12-十四酸酯13-乙酸酯 Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-Acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-9-(tetradecanoyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-5-one; 13-O-Acetyl-12-O-(tetradecanoyl)phorbol
CAS No. 16561-29-8, 63597-44-4 (diastereomer)
项目整合开发状态: Phase I
项目研究机构: State University of New Jersey (Not Determined)
合成路线:The acylation of phorbol (I) with tetradecanoyl chloride (II) in pyridine gives the triacyl phorbol (III),which is selective hydrolyzed with NaOMe in methanol at room temperature to yield the monoacyl phorbol (IV).The acylation of (IV) with acetic anhydride in pyridine at 8 C affords the diacetoxy tetradecanoyloxy phorbol (V).Finally,this compound is monodeacetylated by means of HClO4 in methanol at room temperature to provide the target mixed diacylphorbol.