Glutapyrone

3,5-吡啶二羧酸,4-[[[(1S)-1,3-二羧丙基]氨基]-1,4-二氢-2,6-二甲基-,3,5-二乙基酯,二钠盐 Chemical Name: 4-[N-[1(S),3-Dicarboxypropyl]carbamoyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester disodium salt
CAS No. 92236-42-5, 92236-41-4 (free acid)
项目整合开发状态: Preclinical
项目研究机构: Latvian Institute of Organic Synthesis (Originator)
合成路线:The dihydropyridine-4-carboxylic acid derivative (I) was activated as the pentafluorophenyl ester (II) using pentafluorophenol and DCC.Coupling of the active ester (II) with glutamic acid (III) furnished the N-acyl glutamic acid (IV).Alternatively,(IV) was obtained by coupling of glutamic acid (III) with the pyridine acid (I) via activation with DCC/HOBt.Diacid (IV) was finally treated with NaOH to produce the corresponding disodium salt.

合成路线:In a related method for the preparation of (IV),acid (I) was activated as the mixed anhydride (V) using isobutyl chloroformate.Coupling of anhydride (V) with the silyl ester (VI),prepared from glutamic acid (III) and hexamethyldisilazane,provided amide (IV).