EMD-23448
3-(4-(4-苯基-1,2,3,6-四氢-1-吡啶基)丁基)吲哚盐酸盐 Chemical Name: 3-[4-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]indole; 3-[4-(4-Phenyl-3,4-dehydro-1-piperidyl)butyl]indole; 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indole
CAS No. 73966-53-7, 73966-59-3 (HCl)
项目整合开发状态: Biological Testing
项目研究机构: Merck KGaA (Originator)
合成路线:The reaction of 4-(3-indolyl)butyric acid (I) with 4-phenyl-3,4-dehydropiperidine (II) by means of carbonyldiimidazole (A) in THF gives 3-[4-oxo-4-(4-phenyl-3,4-dehydro-1-piperidyl)butyl]indole (III),which is reduced with LiAlH4 in THF.
合成路线:By condensation of (II) with 3-(4chlorobutyl)indole (IV) in acetonitrile.Other compounds with Br,I or tosyloxy substituents instead of Cl can also be used in the above mentioned synthesis.
📌 参考资料/链接：
参考文献标题:EMD-23,448
文献作者:Blancafort,P.; Hillier,K.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1983,8(5),400
📄 详细内容
合成路线:The reaction of 4-(3-indolyl)butyric acid (I) with 4-phenyl-3,4-dehydropiperidine (II) by means of carbonyldiimidazole (A) in THF gives 3-[4-oxo-4-(4-phenyl-3,4-dehydro-1-piperidyl)butyl]indole (III),which is reduced with LiAlH4 in THF.
合成路线:By condensation of (II) with 3-(4chlorobutyl)indole (IV) in acetonitrile.Other compounds with Br,I or tosyloxy substituents instead of Cl can also be used in the above mentioned synthesis.
参考文献标题:
文献作者:Hausberg,H.H.; Koppe,V.; Poetsch,E.; Saiko,O.; Seyfried,C.
参考来源:US 4251538
产品链接: CAS No. 73966-53-7›› 产品链接: CAS No.73966-59-3››