UCL-1972
1-[5-(4-硝基苯氧基)戊基]吡咯利定Chemical Name: 1-[5-(4-Nitrophenoxy)pentyl]pyrrolidine
CAS No. 220728-17-6
项目整合开发状态: Preclinical
项目研究机构: Bioprojet (Originator), INSERM (Originator)
合成路线:The reaction of 4-nitrophenol (I) with 1,5-dibromopentane (II) and NaOH in refluxing water gives the aryl ether (III),which is finally condensed with pyrrolidine (IV) in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications
文献作者:Stark,H.; Ligneau,X.; Garbarg,M.; Schunack,W.G.; Ganellin,C.R.; Lecomte,J.-M.; Arrang,J.-M.; Leurquin,F.; Sigurd,E.; Schwartz,J.-C.(Societe Civile Bioprojet)
参考来源:EP 0978512
📄 详细内容
合成路线:The reaction of 4-nitrophenol (I) with 1,5-dibromopentane (II) and NaOH in refluxing water gives the aryl ether (III),which is finally condensed with pyrrolidine (IV) in refluxing ethanol.
参考文献标题:Synthesis of potent non-imidazole histamine H3-receptor antagonists
文献作者:Ganellin,C.; et al.
参考来源:Arch Pharm 1998,331(12),395
产品链接: CAS No. 220728-17-6››