NNC-26-9100

1-[3-[N-(5-溴吡啶-2-基)-N-(3,4-二氯苄基)氨基]丙基]-3-[3-(1H-咪唑-4-基)丙基]硫脲Chemical Name: N-[3-[N-(5-Bromo-2-pyridyl)-N-(3,4-dichlorobenzyl)amino]propyl]-N'-[3-(1H-imidazol-4-yl)propyl]thiourea
CAS No. 199522-35-5
项目整合开发状态: Preclinical
项目研究机构: Novo Nordisk (Originator)
合成路线:Reaction of 2,5-dibromopyridine (I) with an excess of 1,3-diaminopropane (II) in refluxing pyridine provided N-1-(2-pyridyl)propanediamine (III).This compound was further alkylated at the 1N with 3,4-dichlorobenzyl chloride (IV) in DMSO using NaH as the base to afford (V).From this,isothiocyanate (VI) was prepared by reaction with CS2 and DCC in THF.Subsequent coupling with trityl-protected amine (VII) yielded the thiourea (VIII).Finally,the trityl protecting group was removed by refluxing in 1 N HCl.