TK-117
1-[1-(4-甲基苯基)丙基]哌啶盐酸Chemical Name: 3-(3',4'-Methylenedioxybenzoyl)-2'-deoxy-5-fluoro-uridine
CAS No. 74234-11-0
项目整合开发状态: Biological Testing
项目研究机构: Toyama (Originator)
合成路线:The acylation of 3',5'-di-O-(chloroacetyl)-5-fluoro-2'-deoxyuridine (I) with 3,4-methylenedioxybenzoyl chloride (II) by means of triethylamine in dichloromethane gives 3',5'-di-O-(chloroacetyl)-3-(3,4-methylenedioxybenzoyl)-2'-deoxy-5-fluorouridine (III),which is then hydrolyzed with triethylamine in methanol-THF.
📌 参考资料/链接：
参考文献标题:5-Fluoro-(beta-uridine or 2'-deoxy-beta-uridine) derivatives,a process for producing the same and a carcinostatic agent containing the same
文献作者:Terashima,N.; Kitayama,I.; Yamaguchi,T.; Hiraiwa,T.; Omori,M.; Senoura,M.; Yotsuji,M.; Kodama,T.; Kodama,Y.; Aoyama,H.(Toyama Chemical Co.,Ltd.)
参考来源:DE 2923368
📄 详细内容
合成路线:The acylation of 3',5'-di-O-(chloroacetyl)-5-fluoro-2'-deoxyuridine (I) with 3,4-methylenedioxybenzoyl chloride (II) by means of triethylamine in dichloromethane gives 3',5'-di-O-(chloroacetyl)-3-(3,4-methylenedioxybenzoyl)-2'-deoxy-5-fluorouridine (III),which is then hydrolyzed with triethylamine in methanol-THF.
参考文献标题:TK-117
文献作者:Castar,J.; Castar,R.M.; Hoshi,A.; Serradell,M.N.
参考来源:Drugs Fut 1987,12(9),865
产品链接: CAS No. 74234-11-0››