Bay-k-8644
1,4-二氢-2,6-二甲基-5-硝基-4-(2-[三氟甲基]苯基)吡啶-3-羧酸甲酯Chemical Name: Methyl 2,6-dimethyl-3-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-5-carboxylate; 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
CAS No. 71145-03-4
项目整合开发状态: Preclinical
项目研究机构: Bayer (Originator)
合成路线:This compound can be obtained by two different ways:1) By cyclization of 2-trifluoromethylbenzaldehyde (I) with methyl 3-amino crotonate (II) and nitropropanone (III) in refluxing ethanol.2) By cyclization of methyl 2-(2-trifluoromethylbenzylidene)acetoacetate (IV) with 2-amino-1-nitropropene (V) in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:Dihydropyridines having a positive inotropic effect,novel compounds,their use in medicaments,and processes for their preparation
文献作者:Bossert,F.; Franckowiak,G.; Boeshagen,H.; Goldmann,S.; Schramm,M.; Thomas,G.; Meyer,H.; Towart,R.; Wehinger,E.(Bayer AG)
参考来源:BE 0893984; DE 3130041; ZA 8205456
📄 详细内容
合成路线:This compound can be obtained by two different ways:1) By cyclization of 2-trifluoromethylbenzaldehyde (I) with methyl 3-amino crotonate (II) and nitropropanone (III) in refluxing ethanol.2) By cyclization of methyl 2-(2-trifluoromethylbenzylidene)acetoacetate (IV) with 2-amino-1-nitropropene (V) in refluxing ethanol.
参考文献标题:Nitro-substituted 1,4-dihydropyridines,processes for their production and their medicinal use
文献作者:Bossert,F.; Franckowiak,G.; Heise,A.; Kazda,S.; Meyer,H.; Stoepel,K.; Towart,R.; Wehinger,E.(Bayer AG)
参考来源:DE 2752820; EP 0002208; ES 475379; ES 480350; ES 480351; JP 54081279
合成路线:This compound can be obtained by two different ways:1) By cyclization of 2-trifluoromethylbenzaldehyde (I) with methyl 3-amino crotonate (II) and nitropropanone (III) in refluxing ethanol.2) By cyclization of methyl 2-(2-trifluoromethylbenzylidene)acetoacetate (IV) with 2-amino-1-nitropropene (V) in refluxing ethanol.
参考文献标题:BAY-K-8644
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1984,9(3),168
产品链接: CAS No. 71145-03-4››