Indometacin farnesil, Indomethacin farnesil, E-0710, Infree
1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1-吲哚-3-乙酸3,7,11-三甲基-2,6,10-十二碳三烯酯Chemical Name: 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid 3,7,11-trimethyl-2,6,10-dodecatrienyl ester
CAS No. 85801-02-1
项目整合开发状态: Launched-1991
项目研究机构: Eisai (Originator)
合成路线:The reacion of 1-(4-chlorobenzoyl)-2-methyl-5-methoxyindolyl-3-acetic acid (I) with SOCl2 in refluxing benzene gives the corresponding acyl chloride (II),which is condensed with farnesol (III) by means of triethylamine in THF.
📌 参考资料/链接：
参考文献标题:Polyprenyl esters of acemethacins and anti-inflammatory method of use thereof
文献作者:Yamatsu,I.; Abe,S.; Inai,Y.; Suzuki,T.; Kinoshita,K.; Mishima,M.; Katoh,Y.; Kobayashi,S.; Murakami,M.; Yamada,K.(Eisai Co.,Ltd.)
参考来源:DE 3226687; FR 2510107; GB 2104513; JP 8315940
📄 详细内容
合成路线:The reacion of 1-(4-chlorobenzoyl)-2-methyl-5-methoxyindolyl-3-acetic acid (I) with SOCl2 in refluxing benzene gives the corresponding acyl chloride (II),which is condensed with farnesol (III) by means of triethylamine in THF.
参考文献标题:E-0710
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(7),506
产品链接: CAS No. 85801-02-1››