SK&F-100330A
1-(4,4-二苯基-3-丁烯基)-1,2,5,6-四氢-3-吡啶羧酸Chemical Name: N-(4,4-Diphenyl-3-butenyl)guvacine hydrochloride; 1-(4,4-Diphenyl-3-butenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride
CAS No. 85375-88-8
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithKline (Originator)
合成路线:The methyl ester of 1,2,5,6-tetrahydro-3-pyridinecarboxylate (guvacine) (II) is N-alkylated with 4,4-diphenyl-3-butenyl bromide (I).The methyl ester of N-(4,4-diphenyl-3-butenyl)guvacine thus obtained is then hydrolvzed with HCl to yield the hydrochloride of the free acid.
📌 参考资料/链接：
参考文献标题:SK&F-100330-A
文献作者:Lcher,W.
参考来源:Drugs Fut 1986,11(1),39
📄 详细内容
合成路线:The ethyl ester of 3-piperidinecarboxylic acid (nipecotic acid) (II) is N-alkylated with 4,4-diphenyl-3-butenyl bromide (I).The ethyl ester of N-(4,4-diphenyl-3-butenyl)nipecotic acid thus obtained is then hydrolyzed with HCl to yield the hydrochloride of the free acid.
合成路线:The methyl ester of 1,2,5,6-tetrahydro-3-pyridinecarboxylate (guvacine) (II) is N-alkylated with 4,4-diphenyl-3-butenyl bromide (I).The methyl ester of N-(4,4-diphenyl-3-butenyl)guvacine thus obtained is then hydrolvzed with HCl to yield the hydrochloride of the free acid.
参考文献标题:Orally active and potent inhibitors of gamma-aminobutyric acid uptake
文献作者:Fe,A.; Bondinell,W.E.; Dandridge,P.A.; Frazee,J.S.; Garvey,E.; Girard,G.R.; Kaiser,C.; Ku,T.W.; Lafferty,J.J.; Moonsammy,G.I.; et al.
参考来源:J Med Chem 1985,28(5),653
产品链接: CAS No. 85375-88-8››