Iobenguane[131I], MIBG, PheoMIBG-I(131) Injection
1-(3-碘苄基)胍 3-碘苄基-胍半硫酸盐 硫酸碘苄胍EP标准品Chemical Name: m-131-Iodobenzylguanidine; [(3-Iodo-[131I])phenyl]methylguanidine
CAS No. 77679-27-7, 139755-80-9 (123I-labeled sulfate(2:1)), 87862-25-7 (non-labeled sulfate (2:1)), 149210-33-3 (sulfate (2:1))
项目整合开发状态: Launched-1993
项目研究机构: University of Michigan (Originator), National Institutes of Health (Not Determined), CIS Bio International (Licensee), Daiichi Radioisotope (Licensee), Neoprobe (Licensee)
合成路线:MIBG is synthesized as follows:A mixture of m-iodobenzylamine (I) hydrochloride and cyanamide (II) is stirred and heated at 100 C for 4h.The resulting m-iodobenzylguanidine is converted to the bicarbonate salt by treatment with aqueous potassium bicarbonate.Addition of dilute sulfuric acid gives the guanidine sulfate.To prepare the labeled compound,the unlabeled m-iodobenzylguanidinium sulfate is dissolved in water and treated with carrier-free Na[131]I.Refluxing for 72h and passage through Cellex D anion exchange cellulose gives [131]iodobenzylguanidine sulfate.Another more efficient method of carrying out the exchange-labeling step has been reported.
📌 参考资料/链接：
参考文献标题:Iobenguane (131I)
文献作者:Eastland,G.Jr.
参考来源:Drugs Fut 1989,14(5),427
📄 详细内容
合成路线:MIBG is synthesized as follows:A mixture of m-iodobenzylamine (I) hydrochloride and cyanamide (II) is stirred and heated at 100 C for 4h.The resulting m-iodobenzylguanidine is converted to the bicarbonate salt by treatment with aqueous potassium bicarbonate.Addition of dilute sulfuric acid gives the guanidine sulfate.To prepare the labeled compound,the unlabeled m-iodobenzylguanidinium sulfate is dissolved in water and treated with carrier-free Na[131]I.Refluxing for 72h and passage through Cellex D anion exchange cellulose gives [131]iodobenzylguanidine sulfate.Another more efficient method of carrying out the exchange-labeling step has been reported.
参考文献标题:Radiolabeled adrenergic neuron-blocking agents: Adrenomedullary imaging with [131]iodobenzylguanidine
文献作者:Wieland,D.M.; Wu,J.-L.; Brown,L.E.; Mengner,T.J.; Swanson,D.P.; Beierwaltes,W.H.
参考来源:J Nucl Med 1980,21349-53
合成路线:MIBG is synthesized as follows:A mixture of m-iodobenzylamine (I) hydrochloride and cyanamide (II) is stirred and heated at 100 C for 4h.The resulting m-iodobenzylguanidine is converted to the bicarbonate salt by treatment with aqueous potassium bicarbonate.Addition of dilute sulfuric acid gives the guanidine sulfate.To prepare the labeled compound,the unlabeled m-iodobenzylguanidinium sulfate is dissolved in water and treated with carrier-free Na[131]I.Refluxing for 72h and passage through Cellex D anion exchange cellulose gives [131]iodobenzylguanidine sulfate.Another more efficient method of carrying out the exchange-labeling step has been reported.
参考文献标题:Iodine-131-m-iodobenzylguanidine for the locating of suspected pheochromocytoma: Experience in 400 cases
文献作者:Shapiro,B.; Copp,J.E.; Sisson,J.C.; Eyres,P.L.; Wallis,J.; Beierwaltes,W.H.
参考来源:J Nucl Med 1985,26576-85