合成路线:The condensation of N-(tert-butoxycarbonyl)-L-tert-butyl-glycine N-succinimidyl ester (I) with L-prolinamide (II) by means of DIEA in dichloromethane gives the dipeptide amide (III),which is dehydrated by means of POCl3 and imidazole in pyridine to yield N-(tert-butoxycarbonyl)-L-tert-butylglycyl-L-prolinenitrile (IV).Finally,this compound is deprotected by means of trifluoroacetic acid to provide the target dipeptide nitrile.
参考文献标题:Compsns.for promoting growth
文献作者:Broqua,P.(Ferring BV Group Holding)
参考来源:WO 0056297
合成路线:The condensation of N-(tert-butoxycarbonyl)-L-tert-butyl-glycine N-succinimidyl ester (I) with L-prolinamide (II) by means of DIEA in dichloromethane gives the dipeptide amide (III),which is dehydrated by means of POCl3 and imidazole in pyridine to yield N-(tert-butoxycarbonyl)-L-tert-butylglycyl-L-prolinenitrile (IV).Finally,this compound is deprotected by means of trifluoroacetic acid to provide the target dipeptide nitrile.
参考文献标题:2-Cyanopyrrolidides as potent,stable inhibitors of dipeptidyl peptidase IV
文献作者:Ashworth,D.M.; et al.
参考来源:Bioorg Med Chem Lett 1996,6(10),1163
产品链接: CAS No. 171092-64-1››