IPdR

1-(2-脱氧-beta-呋喃核糖基)-5-碘-2-嘧啶酮Chemical Name: 1-(2-Deoxy-beta-D-ribofuramosyl)-5-iodo-2-pyrimidinone
CAS No. 93265-81-7
项目整合开发状态: Phase I
项目研究机构: State University of New York, Albany (Originator), Pangene (Not Determined), Hudson Health (Licensee)
合成路线:The condensation of 2-(trimethylsilyloxy)-5-iodopyrimidine (II) with the protected sugar chloride (I) by means of SnCl4 in 1,2-dichloroethane gives the pyrimidinone (II),which is finally deprotected by means of NaHCO3 in methylene chloride/water and isolated from a minor amount of the alpha-isomer by crystallization from ethyl acetate.