TEI-6170(free acid), TT-62
[(2R,3S,5S)-5-(5-氟-2,4-二氧基嘧啶-1-基)-3-羟基氧基-2-基]甲基四甲基四甲基氢磷酸盐Chemical Name: 5-Fluoro-2'-deoxyuridine 5'-myristylphosphate sodium salt; 5-Fluoro-2'-deoxyuridine 5'-tetradecylphosphate sodium salt; 2'-Deoxy-5-fluoro-5'-uridylic acid monotetradecyl ester sodium salt
CAS No. 86976-77-4 (free acid)
项目整合开发状态: Phase II
项目研究机构: Teijin (Originator)
合成路线:By condensation of 3'-O-acetyl-5-fluoro-2'-deoxyuridine (I) with tetradecylphosphoric acid (II) by means of tosyl chloride in anhydrous pyridine followed by deacetylation with ammonia and formation of the sodium salt.
📌 参考资料/链接：
参考文献标题:5-Fluoro-2'-deoxyuridine derivs.and a process for the preparation thereof
文献作者:Watanabe,K.; Saito,M.; Kato,Y.; Oba,T.; Fukushima,H.; Hara,T.(Teijin Ltd.)
参考来源:EP 0081386
📄 详细内容
合成路线:By condensation of 3'-O-acetyl-5-fluoro-2'-deoxyuridine (I) with tetradecylphosphoric acid (II) by means of tosyl chloride in anhydrous pyridine followed by deacetylation with ammonia and formation of the sodium salt.
参考文献标题:5-Fluoro-2'-deoxyuridine derivs.and method for their preparation
文献作者:Watanabe,K.; Kato,Y.; Sato,M.; Oba,T.; Fukushima,H.; Hara,T.(Teijin Ltd.)
参考来源:JP 1984093096
合成路线:By condensation of 3'-O-acetyl-5-fluoro-2'-deoxyuridine (I) with tetradecylphosphoric acid (II) by means of tosyl chloride in anhydrous pyridine followed by deacetylation with ammonia and formation of the sodium salt.
参考文献标题:Antiviral agents which active principles are 5-fluoro-2'-deoxyuridine derivs.
文献作者:Watanabe,K.; Fujinaga,S.(Teijin Ltd.)
参考来源:JP 1987036322
合成路线:By condensation of 3'-O-acetyl-5-fluoro-2'-deoxyuridine (I) with tetradecylphosphoric acid (II) by means of tosyl chloride in anhydrous pyridine followed by deacetylation with ammonia and formation of the sodium salt.
参考文献标题:TT-62
文献作者:Hoshi,A.; Prous,J.; Castar,J.
参考来源:Drugs Fut 1990,15(10),1002
产品链接: CAS No. 86976-77-4››