SDZ-62-834zi, NSC-614383, CRC-8605, SRI-62-834

(四氢-2-(十八烷氧基)甲基呋喃-2-基)甲氧基磷酰胆碱Chemical Name: (?-2-[Hydroxy[2-(octadecyloxymethyl)tetrahydrofuran-2-ylmethoxy]phosphinyloxy]-N,N,N-trimethylethylamminium hydroxyde,inner salt P-oxide
CAS No. 113201-37-9
项目整合开发状态: Phase II
项目研究机构: Novartis (Originator)
合成路线:The reaction of tetrahydrofuran-2,2-dimethanol (I) with 1 mole of octadecyl bromide (II) by means of KOH in DMSO gives the monoether (III),which is finally condensed with 2-chloro-2-oxo-1,3,2-dioxaphospholane (IV) and triethylamine in benzene to afford the target compound.