BGP-15
(Z)-N-(2-羟基-3-(哌啶-1-基)丙氧基)烟酰胺双盐酸盐Chemical Name: N'-[2-Hydroxy-3-(1-piperidinyl)propoxy]pyridine-3-carboxamidine dihydrochloride
CAS No. 66611-37-8 (tautomer)
项目整合开发状态: Discontinued
项目研究机构: N-Gene (Originator), Allos (Licensee), Chinoin (Licensee)
合成路线:N-(2,3-Epoxypropyl)piperidine (III),prepared from piperidine (I) and epichlorhydrin (II),was condensed with nicotinic acid amidoxime (IV) in the presence of basic catalysts,such as NaOH,t-BuOK,Al2O3 or SnO2,in hot DMF to provide the title compound,which was finally converted to the dihydrochloride salt.
合成路线:Alternatively,the title compound was prepared by condensation of nicotinamidoxime (IV) with 1,1-pentamethylene-3-hdroxyazetidinium chloride (V).
📌 参考资料/链接：
参考文献标题:Improved process for the preparation of amidoxime derivs.
文献作者:Somfai,?; Bert髃,B.; Sz閗ely,I.; Tak醕s,K.; Thurner,A.; Gaj醨y,A.; Bot醨,S.; Nagy,L.(Chinoin Pharmaceutical and Chemical Works Co.,Ltd.)
参考来源:WO 9008131
📄 详细内容
合成路线:In a further procedure,nicotinamidoxime (IV) was condensed with 1-chloro-3-piperidino-2-propanol (VI) in the presence of ethanolic NaOEt.
参考文献标题:O-(3-Amino-2-hydroxy-propyl)amidoxime derivs.,process for the preparation thereof and pharmaceutical compsns.containing same
文献作者:Farago,K.; Literati,P.N.; Simay,A.; Takacs,K.; Virag,S.; Szcntivanyi,M.; Kiss,I.(Chinoin Pharmaceutical and Chemical Works Co.,Ltd.)
参考来源:US 4308399
产品链接: CAS No. 66611-37-8››