Alaptide, VUFB-15754, CPA, c(Acp-Ala)
(S)-8-甲基-6,9-二氮杂螺环[4.5]癸烷-7,10-二酮Chemical Name: Cyclo(1-amino-1-cyclopentanecarbonyl-L-alanyl); 6'(S)-Methyl-2',5'-dioxospiro[cyclopentane-1,3'-piperazine]; 8(S)-Methyl-6,9-diazaspiro[4.5]decane-7,10-dione
CAS No. 90058-29-0
项目整合开发状态: Phase III
项目研究机构: Res. Inst. Pharmacy Biochemistry (VUFB) (Originator)
合成路线:The condensation of methyl 1-aminocyclopentane-1-carboxylate (I) with N-benzyloxycarbonyl-alanine (II) by the mixed anhydride method gives methyl 1-(benzyloxycarbonyl-alanyl)aminocyclopentane-1-carboxylate (III).Debenzylation of (III) by hydrogenation with H2 over Pd/C in methanol followed by a cyclization reaction in refluxing toluene yields alaptide.
📌 参考资料/链接：
参考文献标题:2,5-Piperazinedione derivs
文献作者:Kasafirek,E.; Vanzura,J.; Krejci,I.; Krepelka,J.; Dlabac,A.; Valchar,M.(SPOFA - United Pharmaceutical Works)
参考来源:CS 231227; GB 2127807
📄 详细内容
合成路线:The condensation of methyl 1-aminocyclopentane-1-carboxylate (I) with N-benzyloxycarbonyl-alanine (II) by the mixed anhydride method gives methyl 1-(benzyloxycarbonyl-alanyl)aminocyclopentane-1-carboxylate (III).Debenzylation of (III) by hydrogenation with H2 over Pd/C in methanol followed by a cyclization reaction in refluxing toluene yields alaptide.
参考文献标题:ALAPTIDE
文献作者:R醖l,S.; Kasaf韗ek,E.; Krejc? I.
参考来源:Drugs Fut 1990,15(5),445
产品链接: CAS No. 90058-29-0››