Fosteabine sodium hydrate, Cytarabine ocfosfate, C18PCA, YNK01, Starasid

2(1H)-嘧啶酮,4-氨基-1-[5-O-[羟基(辛基氧基)phoshinyl]-b-D-阿拉伯氨脋诺基]-,钠盐(1:1) [(2R,3S,4S)-5-(4-氨基-2-氧代嘧啶-1-基)-3,4-二羟基四氢呋喃-2-基]甲基十八烷基氢磷酸酯Chemical Name: 1-beta-D-Arabinofuranosylcytosine 5'-stearyl phosphate monosodium salt monohydrate
CAS No. 116459-64-4, 65093-40-5 (anhydrous), 73532-83-9 (anhydrous, free acid)
项目整合开发状态: Launched-1992
项目研究机构: Nippon Kayaku (Originator), Asta Medica (Licensee), Yamasa Shoyu (Licensee)
合成路线:Acetylation of 1-beta-D-arabinofuranosylcytosine 5'-monophosphate (I) with acetic anhydride gives acetylated compound (II),which is treated with tosyl chloride and stearyl alcohol to synthesize stearyl ester (IV).Stearyl ester (IV) is deacetylated and converted to sodium salt.