FY-609, HSR-609
1-哌啶丙烷酸,4-(8-氟[1]苯并氧环[4,3-b]吡啶-11(5H)-伊烯)- Chemical Name: 3-[4-(8-Fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidin-1-yl]propionic acid dihydrate
CAS No. 188199-97-5, 161522-25-4 (anhydrous), 153250-51-2 (anhydrous diHBr salt), 153250-07-8 (anhydrous HCl salt)
项目整合开发状态: Phase II
项目研究机构: Abbott (Originator)
合成路线:HSR-609 is obtained as shown in Scheme 20067601a:Tricyclic compound (II),derived from (I) by known methods,is converted to piperidine derivative (III) by Grignard reaction and dehydration.The reaction of (III) with ClCO2Et and KOH affords (IV).Michael reaction and hydrolysis of (IV) give HSR-609.
📌 参考资料/链接：
参考文献标题:Amphoteric tricyclic compounds as antihistaminic and antiallergic agents
文献作者:Ito,Y.; Kato,H.; Yasuda,S.; Kado,N.; Iwasaki,N.; Nishino,H.; Takeshita,M.(Hokuriku Seiyaku Co.,Ltd.)
参考来源:EP 0556813; JP 1994192263; US 5334594
📄 详细内容
合成路线:HSR-609 is obtained as shown in Scheme 20067601a:Tricyclic compound (II),derived from (I) by known methods,is converted to piperidine derivative (III) by Grignard reaction and dehydration.The reaction of (III) with ClCO2Et and KOH affords (IV).Michael reaction and hydrolysis of (IV) give HSR-609.
参考文献标题:Amphoteric drugs.III.Synthesis and antiallergic activity of 3-[(5,11-dihydro[1]benzoxepino[4,3-b]pyridin-11-ylidene)piperidino] propionic acid derivatives and related compounds
文献作者:Iwasaki,N.; Ohashi,T.; Musoh,K.; Nishino,H.; Kado,N.; Yasuda,S.; Kato,H.; Ito,Y.
参考来源:J Med Chem 1995,38(3),496-507
合成路线:HSR-609 is obtained as shown in Scheme 20067601a:Tricyclic compound (II),derived from (I) by known methods,is converted to piperidine derivative (III) by Grignard reaction and dehydration.The reaction of (III) with ClCO2Et and KOH affords (IV).Michael reaction and hydrolysis of (IV) give HSR-609.
参考文献标题:HSR-609
文献作者:Suzuki,T.; Kato,H.; Nagata,O.; Inomata,N.; Ohashi,T.
参考来源:Drugs Fut 1998,23(4),379
产品链接: CAS No. 188199-97-5›› 产品链接: CAS No.161522-25-4››