TPI
(9CI)-5-氯-6-[(2-亚氨基-1-吡咯烷)甲基]-2,4(1H,3H)-嘧啶二酮盐酸盐 替吡嘧啶杂质 Chemical Name: 5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione hydrochloride; 5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)uracil hydrochloride
CAS No. 183204-72-0, 183204-74-2 (free base), 183204-75-3 (monomethanesufonate salt)
项目整合开发状态: Phase I
项目研究机构: Taiho (Originator)
合成路线:The chlorination of 6-(chloromethyl)uracil (I) with sulfuryl chloride in acetic acid gives 5-chloro-6-(chloromethyl)uracil (II),which is then condensed with 2-iminopyrrolidine (III) by means of sodium ethoxide in DMF.
📌 参考资料/链接：
参考文献标题:Uracil derivs.,and antitumor effect potentiator and antitumor agent containing the same
文献作者:Yano,S.; Tada,Y.; Kazuno,H.; Sato,T.; Yamashita,J.; Suzuki,N.; Emura,T.; Fukushima,M.; Asao,T.(Taiho Pharmaceutical Co.,Ltd.)
参考来源:EP 0763529; US 5744475; WO 9630346
📄 详细内容
合成路线:The chlorination of 6-(chloromethyl)uracil (I) with sulfuryl chloride in acetic acid gives 5-chloro-6-(chloromethyl)uracil (II),which is then condensed with 2-iminopyrrolidine (III) by means of sodium ethoxide in DMF.
参考文献标题:Cancerous metastasis inhibitors containing uracil derivs.
文献作者:Miyadera,K.; Emura,T.; Wierzba,K.; Yamada,Y.(Taiho Pharmaceutical Co.,Ltd.)
参考来源:EP 0884051; WO 9813045
产品链接: CAS No. 183204-72-0›› 产品链接: CAS No.183204-74-2››