合成路线:This compound can be prepared in two related ways:1) The catalytic hydrogenation of biopterin (I) with H2 over PtO2 aqueous K2HPO4 at pH 11.4 or aq.(Et)4NOH at pH 12 yields a solution which is acidified with HCl.After evaporation,the residue is crystallized in ethanol - HCl.2) The acetylation of biopterin (I) with refluxing acetic anhydride gives the triacetyl derivative (II),which is hydrogenated with H2 over PtO2 in trifluoroacetic acid,yielding the (6RS)-mixture of triacetyl derivatives (III).Acetylation of (III) with refluxing acetic anhydride affords the tetracetyl (6RS)-derivative (IV),which by fractional crystallization or column chromatography of the dihydrochloride in methanol gives the desired compound as pure (6R)-isomer.
参考文献标题:Method for the preparation of tetrahydro-L-biopterin
文献作者:Tateoka,T.; Ishiguro,M.; Nakatsuka,N.(Suntory Ltd.)
参考来源:JP 1984021685
合成路线:This compound can be prepared in two related ways:1) The catalytic hydrogenation of biopterin (I) with H2 over PtO2 aqueous K2HPO4 at pH 11.4 or aq.(Et)4NOH at pH 12 yields a solution which is acidified with HCl.After evaporation,the residue is crystallized in ethanol - HCl.2) The acetylation of biopterin (I) with refluxing acetic anhydride gives the triacetyl derivative (II),which is hydrogenated with H2 over PtO2 in trifluoroacetic acid,yielding the (6RS)-mixture of triacetyl derivatives (III).Acetylation of (III) with refluxing acetic anhydride affords the tetracetyl (6RS)-derivative (IV),which by fractional crystallization or column chromatography of the dihydrochloride in methanol gives the desired compound as pure (6R)-isomer.
参考文献标题:Sapropterin Dihydrochloride
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1991,16(1),30
合成路线:This compound can be prepared in two related ways:1) The catalytic hydrogenation of biopterin (I) with H2 over PtO2 aqueous K2HPO4 at pH 11.4 or aq.(Et)4NOH at pH 12 yields a solution which is acidified with HCl.After evaporation,the residue is crystallized in ethanol - HCl.2) The acetylation of biopterin (I) with refluxing acetic anhydride gives the triacetyl derivative (II),which is hydrogenated with H2 over PtO2 in trifluoroacetic acid,yielding the (6RS)-mixture of triacetyl derivatives (III).Acetylation of (III) with refluxing acetic anhydride affords the tetracetyl (6RS)-derivative (IV),which by fractional crystallization or column chromatography of the dihydrochloride in methanol gives the desired compound as pure (6R)-isomer.
参考文献标题:Pterin chemistry.72.Separation of the diastereomers (6R)- and (6S)-5,6,7,8-tetrahydro-L-biopterin
文献作者:Viscontini,M.; Bieri,J.H.; Furrer,H.J.
参考来源:Helv Chim Acta 1979,62(8),2577-80
合成路线:This compound can be prepared in two related ways:1) The catalytic hydrogenation of biopterin (I) with H2 over PtO2 aqueous K2HPO4 at pH 11.4 or aq.(Et)4NOH at pH 12 yields a solution which is acidified with HCl.After evaporation,the residue is crystallized in ethanol - HCl.2) The acetylation of biopterin (I) with refluxing acetic anhydride gives the triacetyl derivative (II),which is hydrogenated with H2 over PtO2 in trifluoroacetic acid,yielding the (6RS)-mixture of triacetyl derivatives (III).Acetylation of (III) with refluxing acetic anhydride affords the tetracetyl (6RS)-derivative (IV),which by fractional crystallization or column chromatography of the dihydrochloride in methanol gives the desired compound as pure (6R)-isomer.
参考文献标题:Highly stereoselective procedure for (6R)-tetrahydrobiopterin cofactor
文献作者:Matsuura,S.; Murata,S.; Sugimoto,T.
参考来源:Chem Lett 1984,5(5),735-8
合成路线:This compound can be prepared in two related ways:1) The catalytic hydrogenation of biopterin (I) with H2 over PtO2 aqueous K2HPO4 at pH 11.4 or aq.(Et)4NOH at pH 12 yields a solution which is acidified with HCl.After evaporation,the residue is crystallized in ethanol - HCl.2) The acetylation of biopterin (I) with refluxing acetic anhydride gives the triacetyl derivative (II),which is hydrogenated with H2 over PtO2 in trifluoroacetic acid,yielding the (6RS)-mixture of triacetyl derivatives (III).Acetylation of (III) with refluxing acetic anhydride affords the tetracetyl (6RS)-derivative (IV),which by fractional crystallization or column chromatography of the dihydrochloride in methanol gives the desired compound as pure (6R)-isomer.
参考文献标题:IX.The conformations of (6R)- and (6S)-2-amino-6-[(1'R,2'S)-1',2'-dihydroxypropyl]-5,6,7,8-tetra- hydropteridin-4(3H)-one [L-erythro-5,6,7,8-tetrahydrobiopterin] hydrochlorides and their tetraacetyl derivatives
文献作者:Randles,D.; Taguchi,H.; Whittaker,M.J.Pterins.; Armarego,W.L.F.
参考来源:Aust J Chem 1984,37(2),355-66
产品链接: CAS No. 69056-38-8›› 产品链接: CAS No.62989-33-7››