合成路线:Condensation of benzoyl chloride (I) with ammonium thiocyanate in boiling acetone produces benzoyl isothiocyanate (II).This is then coupled with the known 3-amino-5-phenyl-1,2,4-thiadiazole (III) to afford the N-benzoyl thiourea (IV) (1).Finally,hydrolysis of (IV) under alkaline conditions gives rise to the target thiadiazolyl thiourea
参考文献标题:Viral treatment
文献作者:Camden,J.B.(The Procter & Gamble Co.)
参考来源:JP 2002540150; US 6245788; WO 0057869
合成路线:Condensation of benzoyl chloride (I) with ammonium thiocyanate in boiling acetone produces benzoyl isothiocyanate (II).This is then coupled with the known 3-amino-5-phenyl-1,2,4-thiadiazole (III) to afford the N-benzoyl thiourea (IV) (1).Finally,hydrolysis of (IV) under alkaline conditions gives rise to the target thiadiazolyl thiourea
参考文献标题:Viral treatment
文献作者:Camden,J.B.(The Procter & Gamble Co.)
参考来源:US 6340696
合成路线:Condensation of benzoyl chloride (I) with ammonium thiocyanate in boiling acetone produces benzoyl isothiocyanate (II).This is then coupled with the known 3-amino-5-phenyl-1,2,4-thiadiazole (III) to afford the N-benzoyl thiourea (IV) (1).Finally,hydrolysis of (IV) under alkaline conditions gives rise to the target thiadiazolyl thiourea
参考文献标题:Process for the preparation of 1,2,4-thiadiazoles
文献作者:Agyin,J.K.(The Procter & Gamble Co.)
参考来源:US 6297384
合成路线:Condensation of benzoyl chloride (I) with ammonium thiocyanate in boiling acetone produces benzoyl isothiocyanate (II).This is then coupled with the known 3-amino-5-phenyl-1,2,4-thiadiazole (III) to afford the N-benzoyl thiourea (IV) (1).Finally,hydrolysis of (IV) under alkaline conditions gives rise to the target thiadiazolyl thiourea
参考文献标题:1,2,4-Thiadiazolylureas.A postcript to the oxidative cyclisation of thionoamidines
文献作者:Kurzer,F.
参考来源:J Chem Soc - Perkins Trans I 1985,(2),311
合成路线:In a similar method,3-amino-5-phenyl-1,2,4-tiadiazole (I) is coupled with ethoxycarbonyl isothiocyanate to give the N-(ethoxycarbonyl)thiourea (II),which is then hydrolyzed to the title compound under alkaline conditions
参考文献标题:Addition-cyclisations of ethoxycarbonyl isothiocyanate with hydrazine derivatives as a source of thiadiazoles and triazoles
文献作者:Kurzer,F.; Secker,J.L.
参考来源:J Heterocycl Chem 1989,26(2),355
产品链接: CAS No. 97149-60-5››