UCM-707
(5Z,8Z,11Z,14Z)-N-(3-呋喃基甲基)-5,8,11,14-二十碳四烯酰胺Chemical Name: N-(Furan-3-ylmethyl)-5(Z),8(Z),11(Z),14(Z)-icosatetraenamide
CAS No. 390824-20-1
项目整合开发状态: Preclinical
项目研究机构: Universidad Complutense de Madrid (Originator)
合成路线:Arachidonic acid (I) is converted to the corresponding acid chloride (II) by treatment with oxalyl chloride and DMF.Subsequent condensation of acid chloride (II) with 3-furylmethylamine (III) leads to the desired arachidonic acid amide.
📌 参考资料/链接：
参考文献标题:Novel araquidonic acid derivs.with affinity toward the anandamide transporter
文献作者:Lopez Rodriguez,M.L.; Viso Beronda,A.; Ortega Gutierrez,S.; Latres Becker,I.; Gonzalez Rodriguez de Castro,S.; Fernandez Ruiz,J.J.; Ramos Atance,J.A.(Universidad Complutense de Madrid)
参考来源:WO 0212167
📄 详细内容
合成路线:Arachidonic acid (I) is converted to the corresponding acid chloride (II) by treatment with oxalyl chloride and DMF.Subsequent condensation of acid chloride (II) with 3-furylmethylamine (III) leads to the desired arachidonic acid amide.
参考文献标题:Design,synthesis and biological evaluation of novel arachidonic acis derivatives as highly potent and selective endocannabinoid transporter inhibitors
文献作者:L髉ez-Rodr韌uez,M.L.; Viso,A.; Ortega-Guti閞rez,S.; Lastres-Becker,I.; Gonz醠ez,S.; Fern醤dez-Ruiz,J.; Ramos,J.A.
参考来源:J Med Chem 2001,44(26),4505
产品链接: CAS No. 390824-20-1››