BAY-36-7620

(3aS,6aS)-六氢-5-亚甲基-6a-(2-萘甲基)-1H-环戊[c]呋喃-1-酮Chemical Name: (3aS,6aS)-5-Methylene-6a-(naphthalen-2-ylmethyl)perhydrocyclopenta[c]furan-1-one
CAS No. 232605-26-4, 232605-25-3 (racemate)
项目整合开发状态: Preclinical
项目研究机构: Bayer (Originator)
合成路线:The previously reported chiral cyclopentanedicarboxylic acid monoester (I) was converted to the mixed anhydride (II) by treatment with ethyl chloroformate in the presence of triethylamine.Reduction of the mixed anhydride (II) with NaBH4 in cold MeOH produced the corresponding alcohol,which,under the reaction conditions,gave rise to the bicyclic lactone (III).Then,the lithium enolate generated from lactone (III) and lithium hexamethyldisilazide was alkylated with 2-(bromomethyl)naphthalene (IV) to produce the title compound.