Aspalatone, AAME, BK-111
(2-甲基-4-氧代吡喃-3-基)2-乙酰基氧基苯甲酸酯Chemical Name: Acetylsalicylic acid maltol ester; 2-(Acetoxy)benzoic acid 2-methyl-4-oxo-4H-pyran-3-yl ester
CAS No. 147249-33-0
项目整合开发状态: Preclinical
项目研究机构: Bukwang (Originator)
合成路线:Acetylsalicylic (I) acid was refluxed in SOCl2 to give acetylsalicylyl chloride (II),which is condensed with maltol (III) by means of triethylamine in chloroform to afford aspalatone.
📌 参考资料/链接：
参考文献标题:Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity
文献作者:Han,B.H.; Suh,D.-Y.; Yang,H.O.; Park,Y.-H.; Kang,Y.H.; Kim,Y.C.
参考来源:Arzneim-Forsch Drug Res 1994,44(10),1122-6
📄 详细内容
合成路线:Acetylsalicylic (I) acid was refluxed in SOCl2 to give acetylsalicylyl chloride (II),which is condensed with maltol (III) by means of triethylamine in chloroform to afford aspalatone.
参考文献标题:Aspalatone
文献作者:Han,B.H.
参考来源:Drugs Fut 1995,20(11),1109
合成路线:Acetylsalicylic (I) acid was refluxed in SOCl2 to give acetylsalicylyl chloride (II),which is condensed with maltol (III) by means of triethylamine in chloroform to afford aspalatone.
参考文献标题:The aspirin papers
文献作者:Underwood,M.J.; More,R.S.
参考来源:Brit Med J 1994,30871-2
产品链接: CAS No. 147249-33-0››