Fedotozine tartrate, JO-1196

(2S,3S)-2,3-二羟基琥珀酸-(2R)-N,N-二甲基-2-苯基-1-[(3,4,5-三甲氧基苄基)氧基]-2-丁胺(1:1) 费朵托嗪 Chemical Name: (+)-(R)-alpha-Ethyl-N,N-dimethyl-alpha-(3,4,5-trimethoxyphenylmethoxymethyl)benzenemethanamine l-tartrate; (+)-R-alpha-Ethyl-N,N-dimethyl-alpha-(3,4,5-trimethoxybenzyloxymethyl)benzylamine (-)-tartrate; (+)-R-N,N-Dimethyl-1-[(3,4,5-trimethoxybenzyl)oxymethyl]-1-phenylpropylamine l-tartrate
CAS No. 133267-27-3, 123618-00-8 (free base), 78483-34-8 (racemic, free base)
项目整合开发状态: Pre-Registered
项目研究机构: Jouveinal (Originator), Pfizer (Originator)
合成路线:Fedotozine (-)-tartrate can be prepared by two different methods:a) Conventional resolution in ethanol of racemic (?-N,N-dimethyl-1-[(3,4,5-trimethoxybenzyl)oxymethyl]-1-phenyl-n-propylamine with (-)-tartaric acid.b) Condensation of (+)-2-dimethylamino-2-phenyl-n-butanol (I) with 3,4,5-trimethoxybenzyl chloride (II) gives (+)-N,N-dimethyl-1-[(3,4,5-trimethoxybenzyl)oxymethyl]-1-phenyl-n-propylamine,which is salified with (-)-tartaric acid in ethanol to give fedotozine (-)-tartrate.