ST-789, PCF-39

(2S)-5-(二氨基亚甲基氨基)-2-[5-(6-氧代-3H-嘌呤-9-基)戊氧基羰基氨基]戊酸Chemical Name: N2-[5-(Hypoxanthin-9-yl)pentyloxycarbonyl]-L-arginine; Nalpha-5-(1,6-Dihydro-6-oxo-9-purinyl)pentyloxycarbonyl-L-arginine
CAS No. 104317-64-8
项目整合开发状态: Phase I
项目研究机构: Gaslini Univ. (Originator), Sigma-Tau (Originator)
合成路线:The reaction of 4,6-dichloropyrimidin-5-amine (I) with 5-aminopentanol (I) gives 4-chloro-6-(5-hydroxypentylamino)pyrimidin-5 amine (III),which is cyclized with triethyl orthoformate (IV) yielding 6-chloro-9-(5-hydroxypentyl)purine (V).The hydrolysis of (V) with formic acid affords 9-(5-hydroxypentyl) hypoxanthine (VI),which is treated with phosgene (VII) to give 9-[5-(chlorocarbonyloxy)pentyl]hypoxanthine (VIII).Finally,this compound is condensed with arginine (IX).