Wy-50295 tromethamine
(2S)-2-[6-(喹啉-2-基甲氧基)萘-2-基]丙酸Chemical Name: S-(+)-alpha-Methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid 2-hydroxy-1,1-bis(hydroxymethyl)ethylamine salt
CAS No. 123016-21-7 (free acid)
项目整合开发状态: Phase II
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:Alkylation of the disodium salt of the known optically active hydroxyacid (I) with 2-chloromethylquinoline (II) in DMF afforded Wy-50,295 free acid (III).This was reacted with tromethamine in aqueous ethanol to afford the salt (IV).
📌 参考资料/链接：
参考文献标题:2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
文献作者:Kreft,A.F.; Musser,J.H.; Bicksler,J.J.; Giberson,J.W.; Kubrak,D.M.(American Home Products Corp.)
参考来源:AU 8819209; EP 0301813; GB 2207428; US 5208344
📄 详细内容
合成路线:Alkylation of the disodium salt of the known optically active hydroxyacid (I) with 2-chloromethylquinoline (II) in DMF afforded Wy-50,295 free acid (III).This was reacted with tromethamine in aqueous ethanol to afford the salt (IV).
参考文献标题:Determination of the absolute configurations of (+)-2-(6-methoxy-2-naphthyl)propionic acid
文献作者:Maddox,M.L.; Riegl,J.; Harrison,I.T.
参考来源:J Med Chem 1974,17377
合成路线:Alkylation of the disodium salt of the known optically active hydroxyacid (I) with 2-chloromethylquinoline (II) in DMF afforded Wy-50,295 free acid (III).This was reacted with tromethamine in aqueous ethanol to afford the salt (IV).
参考文献标题:Wy-50,295 TROMETHAMINE
文献作者:Kreft,A.; Musser,J.; Marshall,L.; Grimes,D.
参考来源:Drugs Fut 1990,15(8),805
产品链接: CAS No. 123016-21-7››