PK-9084
Chemical Name: 2-Phenyl-4-(2-piperidin-3-ylethyl)quinoline; 2-Phenyl-4-[2-(3-piperidinyl)ethyl]quinoline
CAS No. 77472-99-2
项目整合开发状态: Biological Testing
项目研究机构: Pharmuka (Originator)
合成路线:The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with N-benzoylpipepidine-3-acetic acid ethyl ester (II) by means of potassium hydride in THF gives 2-phenyl-4-[2-(3-piperidyl)acetyl]quinoline (III),which is reduced with hydrazine in dietyleneglycol at 180 C.
📌 参考资料/链接：
参考文献标题:1-(4 Quinolyl) 2- or 3- (2- or 3- piperidyl or pyrrolidinyl) ethanone or propanone,process for their preparation and their use as medicaments
文献作者:Dubroeucq,M.C.; Gueremy,C.G.A.; Lefur,G.R.; Mizoule,J.(Pharmindustrie)
参考来源:EP 0042781
📄 详细内容
合成路线:The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with ethyl N-benzoylpiperidyl-4-acetate (II) by means of potassium tert-butylate in THF gives 2-phenyl-4-(4-piperidylacetyl)quinone (III),which is then reduced with hydrazine at 180 C.
合成路线:The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with N-benzoylpipepidine-3-acetic acid ethyl ester (II) by means of potassium hydride in THF gives 2-phenyl-4-[2-(3-piperidyl)acetyl]quinoline (III),which is reduced with hydrazine in dietyleneglycol at 180 C.
参考文献标题:PK-8165 and PK-9084
文献作者:Blancafort,P.; McGillion,F.B.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1982,7(9),648
产品链接: CAS No. 77472-99-2››