SGB-1534
Chemical Name: 3-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-2,4-(1H,3H)-quinazolinedione monohydrochloride
CAS No. 88068-72-8
项目整合开发状态: Phase II
项目研究机构: Chugai (Originator)
合成路线:This compound can be obtained by two related ways:1) By cyclization of 1-(2-methoxyphenyl)-4-[2-(2-aminobenzoyl)amino-ethyl]piperazine (I) with trichloromethyl chloroformate,with triethylamine as condensing agent and methylene chloride as solvent.2) By cyclization of 1-(2-methoxyphenyl)-4-[2-(2-aminobenzoyl)amino-ethyl]piperazine (I) with urea by heating at 180 C in DMF.
📌 参考资料/链接：
参考文献标题:Phenylpiperazine derivatives
文献作者:Nagano,H.; et al.(Chugai Pharmaceutical Co.Ltd.)
参考来源:EP 0089065; JP 58159480; US 4578465
📄 详细内容
合成路线:This compound can be obtained by two related ways:1) By cyclization of 1-(2-methoxyphenyl)-4-[2-(2-aminobenzoyl)amino-ethyl]piperazine (I) with trichloromethyl chloroformate,with triethylamine as condensing agent and methylene chloride as solvent.2) By cyclization of 1-(2-methoxyphenyl)-4-[2-(2-aminobenzoyl)amino-ethyl]piperazine (I) with urea by heating at 180 C in DMF.
参考文献标题:SGB-1534
文献作者:Castar,J.; Serradell,M.N.; Mannhold,R.
参考来源:Drugs Fut 1985,10(12),993