CL-232468

Chemical Name: 1,4-Bis[(2-aminoethyl)amino]-5,8-dihydroxy-9,10-anthracenedione
CAS No. 70476-81-2
项目整合开发状态: Biological Testing
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:By condensation of 1,4,5,8-tetrahydroxyanthraquinone (I) with ethylenediamine (II) in hot tetramethylethylenediamine.
📌 参考资料/链接:
参考文献标题:1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
文献作者:Durr,F.E.; Murdock,K.C.(American Cyanamid Co.)
参考来源:US 4197249

📄 详细内容


合成路线:By condensation of 1,4,5,8-tetrahydroxyanthraquinone (I) with ethylenediamine (II) in hot tetramethylethylenediamine.

参考文献标题:CL-232468
文献作者:Castar,J.; Arrigoni-Martelli,E.; Serradell,M.N.
参考来源:Drugs Fut 1985,10(5),376


合成路线:By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol,followed by oxidation with air and treatment with acetic acid.

合成路线:By condensation of 1,4,5,8-tetrahydroxyanthraquinone (I) with ethylenediamine (II) in hot tetramethylethylenediamine.
参考文献标题:Antitumor agents.1.1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones
文献作者:Murdock,K.C.; Child,R.G.; Fabio,P.F.; Angier,R.B.; Wallace,R.E.; Durr,F.E.; Citarella,R.V.
参考来源:J Med Chem 1979,22(9),1024


产品链接: CAS No. 70476-81-2››