Ro-220654
Chemical Name: 4-Amino-5-ethyl-3-thiophenecarboxylic acid methyl ester hydrochloride; Methyl 3-amino-2-ethyl-4-thiophenecarboxylate hydrochloride
CAS No. 66319-20-8
项目整合开发状态: Biological Testing
项目研究机构: Roche (Originator)
合成路线:The cyclization of 2-ethyl-3-thia-1,6-hexanedioic acid 1-ethyl-6-methyl ester (I) by means of sodium methoxide in benzene gives methyl 2-ethyl-3-oxotetrahydrothiophene-4-carboxylate (II),which is treated with hydroxylamine in pyridine to afford the corresponding oxime (III).Finally,this compound is treated with dry HCl in ether.
📌 参考资料/链接：
参考文献标题:Novel thiophene derivatives
文献作者:Confalone,P.N.; Pizzolato,G.; Uskokovic,M.R.; Rouge,M.(Hoffmann-La Roche,Inc.)
参考来源:DE 2737738; US 4317915
📄 详细内容
合成路线:The cyclization of 2-ethyl-3-thia-1,6-hexanedioic acid 1-ethyl-6-methyl ester (I) by means of sodium methoxide in benzene gives methyl 2-ethyl-3-oxotetrahydrothiophene-4-carboxylate (II),which is treated with hydroxylamine in pyridine to afford the corresponding oxime (III).Finally,this compound is treated with dry HCl in ether.
参考文献标题:RO-220654
文献作者:Thorpe,P.J.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1985,10(5),407