CGP-15720A
Chemical Name: 1-[2-[2-(4-Pyridyl)-2-imidazolin-1-yl]ethyl]-3-(4-carboxyphenyl)urea hydrochloride; 4-[3-[2-[4,5-Dihydro-2-(4-pyridinyl)-1H-imidazol-1-yl]ethyl]ureido]benzoic acid hydrochloride
CAS No. 73998-70-6, 73998-69-3 (free base)
项目整合开发状态: Biological Testing
项目研究机构: Novartis (Originator)
合成路线:The condensation of 1-(2-aminoethyt)-2-(4 pyridyl)-2-imidazoline (I) with 4-(ethoxycarbonyl)phenyi isocyanate (II) gives the corresponding urea (III),which is hydrolyzed with NaOH in 95% ethanol.
📌 参考资料/链接：
参考文献标题:Imidazole urea and amino compounds
文献作者:Marxer,A.(Novartis Corp.)
参考来源:EP 0004561; GB 2016011; JP 79125668; SA 7901062; US 4292429
📄 详细内容
合成路线:The condensation of 1-(2-aminoethyt)-2-(4 pyridyl)-2-imidazoline (I) with 4-(ethoxycarbonyl)phenyi isocyanate (II) gives the corresponding urea (III),which is hydrolyzed with NaOH in 95% ethanol.
参考文献标题:CGP-15720 A
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(8),641
产品链接: CAS No.73998-69-3››