Bifluranol, BX-341
Chemical Name: erythro-4,4'-(1-Ethyl-2-methylethylene)bis[2-fluorophenol]; erythro-2,3-Bis(3-fluoro-4-hydroxyphenyl)pentane; erythro-3,3'-Difluoro-4,4'-dihydroxy-alpha-methyl-alpha'-ethyldibenzyl; (R*,S*)-4,4'-(1-Ethyl-2-methyl-1,2-ethanediyl)bis[2-fluorophenol]
CAS No. 34633-34-6
项目整合开发状态: Phase III
项目研究机构: Biorex Laboratories (Originator)
合成路线:This compound can be prepared in two different ways:1) The condensation of 3-chloro-2-pentanone (I) with 2-fluoroanisole (II) by means of concentrated H2SO4 and subsequent heating at 240 C gives 2,3-bis(3-fluoro-4-methoxyphenyl)-2-pentene (III),which is reduced with H2 over Pd/C in anhydrous AcOH to afford 2,3-bis(3-fluoro-4-methoxyphenyl)pentane (IV).Finally,this compound is demethylated by treatment with refluxing aqueous HBr.2) The Friedel-Kraft's condensation of (II) with 3-chloro-2-pentanol by means of AlCl3 also gives (IV).
📌 参考资料/链接：
参考文献标题:Bifluranol
文献作者:Castar,J.; Hopkins,S.J.
参考来源:Drugs Fut 1981,6(9),531
📄 详细内容
合成路线:This compound can be prepared in two different ways:1) The condensation of 3-chloro-2-pentanone (I) with 2-fluoroanisole (II) by means of concentrated H2SO4 and subsequent heating at 240 C gives 2,3-bis(3-fluoro-4-methoxyphenyl)-2-pentene (III),which is reduced with H2 over Pd/C in anhydrous AcOH to afford 2,3-bis(3-fluoro-4-methoxyphenyl)pentane (IV).Finally,this compound is demethylated by treatment with refluxing aqueous HBr.2) The Friedel-Kraft's condensation of (II) with 3-chloro-2-pentanol by means of AlCl3 also gives (IV).
参考文献标题:
文献作者:Turner,J.C.; Chan,R.P.-K.
参考来源:US 4051263
产品链接: CAS No. 34633-34-6››